Inhibition of RVLM synaptic activation at peak hyperthermia reduces visceral sympathetic nerve discharge
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چکیده
منابع مشابه
Inhibition of RVLM synaptic activation at peak hyperthermia reduces visceral sympathetic nerve discharge.
Hyperthermia is an environmental stressor that produces marked increases in visceral sympathetic nerve discharge (SND) in young rats. The brainstem in rats contains the essential neural circuitry for mediating visceral sympathetic activation; however, specific brainstem sites involved remain virtually unknown. The rostral ventral lateral medulla (RVLM) is a key central nervous system region inv...
متن کاملDisinhibition of RVLM neural circuits and regulation of sympathetic nerve discharge at peak hyperthermia.
Hyperthermia is a potent activator of visceral sympathetic nerve discharge (SND), and the functional integrity of the rostral ventral lateral medulla (RVLM) is critically important for sustaining sympathoexcitation at peak hyperthermia. However, RVLM mechanisms mediating SND activation to acute heat stress are not well understood. Because RVLM GABA is tonically inhibitory to sympathetic nerve o...
متن کاملIs visceral sympathoexcitation to heat stress dependent on activation of ionotropic excitatory amino acid receptors in the rostral ventrolateral medulla?
Acute heat stress activates visceral sympathetic nerve discharge (SND) in young rats, and the functional integrity of the rostral ventrolateral medulla (RVLM) is required for sustaining visceral sympathoexcitation during peak increases in internal body temperature (T(c)). However, RVLM mechanisms mediating SND activation to hyperthermia remain unknown. In the present study, we investigated the ...
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ژورنال
عنوان ژورنال: Autonomic Neuroscience
سال: 2009
ISSN: 1566-0702
DOI: 10.1016/j.autneu.2009.06.004